Trazodone
In brief
Depression accompanied by anxiety or disturbed sleep may be treated with trazodone. It affects serotonin signalling and often has a sedating effect.
Questions and answers about Trazodone
I don’t have a prescription. Can I buy Trazodone at your pharmacy?
In our online pharmacy, you can purchase Trazodone without a prescription. We guarantee a seamless purchasing experience by providing access to high-quality medication in an easy and confidential manner.
Is it possible that Trazodone doesn’t work?
Trazodone may not be effective for some individuals due to variations in individual responses to medications.
Can anyone see the contents of my order?
No, the contents of your order with Trazodone are strictly confidential. All orders are securely packaged without any external labelling that could reveal the contents, ensuring absolute discretion. We prioritise the privacy of our customers, and no third party will be informed of the details of your order.
What is Trazodone and how does it work?
Trazodone is an antidepressant medication used to treat depression. It works by increasing the levels of serotonin, a neurotransmitter that regulates mood, in the brain.
Is it legal to use Trazodone in the United Kingdom?
Yes, trazodone is a prescription-only medicine (POM) in the United Kingdom; it requires a valid prescription from a licensed healthcare provider to legally obtain and use it.
Mechanism of action of Trazodone
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI): it blocks serotonin 5-HT2A receptors and weakly inhibits the reuptake of serotonin, which helps improve sleep and mood regulation.
How long does it take for Trazodone to work?
Trazodone typically starts working within an hour for insomnia, but it may take 2–4 weeks of regular use to experience its full effects for depression or anxiety.
How long does the effect of Trazodone last?
Trazodone’s effects typically last for around 6-8 hours, with the sedative effects wearing off sooner than the antidepressant effects.
What are the risks of misuse of Trazodone?
Trazodone misuse can lead to drowsiness, dizziness, dry mouth, and potential dependence. It should only be used as prescribed by a healthcare professional.
How long does Trazodone stay in the body?
The half-life of Trazodone is around 5-9 hours, and it can stay in the body for up to a day after the last dose.
Will Trazodone show up in a drug test?
Trazodone is not routinely tested for in standard drug screens, although it has occasionally been reported to cause false-positive results for amphetamines on some urine immunoassays.
Compatibility of Trazodone with other medications
Trazodone can interact with: – Antidepressants (SSRIs, SNRIs, MAOIs) – Sedatives (benzodiazepines, barbiturates) – Antipsychotics – Anticonvulsants – Blood thinners (warfarin) – Certain antibiotics – Alcohol Consult with your healthcare provider for personalised advice.
Can one consume alcohol while taking Trazodone?
Alcohol should be avoided while taking Trazodone, as it can increase drowsiness and dizziness. Your healthcare provider can offer personalised advice based on your overall health condition, medication dosage, and potential risks of interactions.
Recommended storage method for Trazodone
Store Trazodone at room temperature away from light, heat, and moisture. Keep the container tightly closed when not in use.
- Do not freeze.
- Protect from light and moisture.
- Keep out of reach of children and pets.
How should Trazodone be taken and in what dosage?
Trazodone should be taken orally, after food, either as a single dose at bedtime or in divided doses. For depression, the usual starting dosage for adults is 150 mg per day, which can be increased to 300 mg per day if needed; lower doses (for example 75 mg per day) are used for anxiety. It should be taken as follows:
| How to take | Dosage |
|---|---|
| Swallow the tablet(s) whole with water | 150 mg daily, at bedtime or in divided doses |
| Do not stop taking it abruptly | Can be increased up to 300 mg per day |
| Take after food | Follow your doctor’s instructions |
Can Trazodone be taken for an extended period?
Trazodone can be taken for an extended period under medical supervision, but long-term use should be discussed with a healthcare provider to ensure safety and effectiveness.
Overdose of Trazodone and what to do in case of an overdose
An overdose of Trazodone can be harmful, so it is important to seek medical assistance promptly. If you suspect an overdose, you should:
- Contact your doctor or NHS 111 immediately for professional advice, or call 999 in an emergency.
- Closely follow the instructions from your healthcare provider.
- Avoid taking additional doses without consulting a doctor.
Remember, prompt action is crucial.
Comparison of Trazodone with other analogues
| Medicine | Description |
|---|---|
| trazodone | trazodone hydrochloride |
| sertraline | sertraline hydrochloride |
| paroxetine | paroxetine hydrochloride |
| mirtazapine | mirtazapine |
| fluoxetine | fluoxetine hydrochloride |
| venlafaxine | venlafaxine hydrochloride |
| duloxetine | duloxetine hydrochloride |
| escitalopram | escitalopram oxalate |
| amitriptyline | amitriptyline hydrochloride |
| clomipramine | clomipramine hydrochloride |
Trazodone is an antidepressant medication that belongs to the serotonin antagonist and reuptake inhibitor (SARI) class. It is structurally different from other antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin–noradrenaline reuptake inhibitors (SNRIs), which may contribute to its unique side effect profile and therapeutic effects.
What you should know before taking Trazodone
Trazodone is a prescription antidepressant that can cause drowsiness, dizziness, and dry mouth. It should be taken as directed and not stopped abruptly. Consult your doctor about potential side effects and interactions with other medications.
Contraindications for the use of Trazodone
Trazodone should be used with caution in individuals with cardiovascular disorders, liver or kidney disease, and in those taking certain medications that may interact with it. Contraindications for Trazodone include: hypersensitivity to the drug, severe liver impairment, and concurrent use of MAO inhibitors. It’s essential to consult a healthcare professional before taking Trazodone.
Possible side effects of Trazodone
Trazodone is generally well-tolerated, but some possible side effects include drowsiness, dizziness, dry mouth, and constipation. More serious side effects like irregular heartbeat or priapism (prolonged erection) are rare. Here are some common side effects:
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Blurred vision
- Headache
- Nausea
Lifestyle: diet and physical activity
Trazodone may affect diet and exercise routines; consult your doctor before making lifestyle changes while taking this medication.
How does mental state affect the effectiveness of Trazodone
Trazodone’s effectiveness can be influenced by an individual’s mental state, such as depression or anxiety levels. A positive mental outlook may enhance its therapeutic benefits, while persistent negative thoughts or moods could potentially diminish its efficacy.
When should one consult a doctor?
If you experience any unusual side effects, such as dizziness, drowsiness, or confusion, it’s recommended to consult a doctor. Also, consult a doctor if you plan to use Trazodone for an extended period or if you have any pre-existing medical conditions. It’s important to follow the prescribed dosage and guidelines for safe usage.
In which cities can Trazodone be delivered?
Trazodone is available for delivery in the following cities in the United Kingdom:
| City | Region | Delivery Time |
|---|---|---|
| London | Greater London | 9–21 days |
| Birmingham | West Midlands | 9–21 days |
| Manchester | North West England | 9–21 days |
| Liverpool | North West England | 9–21 days |
| Leeds | Yorkshire and the Humber | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Newcastle upon Tyne | North East England | 9–21 days |
| Sheffield | Yorkshire and the Humber | 9–21 days |
| Bristol | South West England | 9–21 days |
| Edinburgh | Scotland | 9–21 days |
| Belfast | Northern Ireland | 9–21 days |
| Cardiff | Wales | 9–21 days |
For additional locations and delivery enquiries, please contact our support team.