Disulfiram
In brief
- Disulfiram at Leader Pharma is available as 250mg tablets, in packs from 30 up to 360, or as 500mg tablets up to 180 per pack; please allow 9–21 days for delivery.
- In Britain it is licensed as an adjunct for people with alcohol dependence who have chosen to stop drinking and have specialist support; the strength licensed in the UK is 200 mg.
- According to the UK SmPC, the first day’s dose is 800 mg, which is reduced over five days to a maintenance dose of 100–200 mg a day, with regular medical review.
- Any alcohol, including that hidden in medicines, foods or toiletries, can set off a reaction such as flushing, throbbing headache, sickness, a racing heart and, in severe cases, collapse.
- Disulfiram is unsuitable for people with heart failure, coronary artery disease or psychosis, and the first dose comes at least 24 hours after the last drink; it is a prescription-only medicine.
Questions and answers about Disulfiram
I don’t have a prescription. Can I buy Disulfiram at your pharmacy?
In our online pharmacy, you can purchase Disulfiram without a prescription. We guarantee a seamless purchasing experience by providing access to high-quality medication in an easy and confidential manner.
Is it possible that Disulfiram doesn’t work?
Disulfiram is generally effective, but individual responses may vary. Consulting a healthcare professional is recommended for proper use and monitoring.
Can anyone see the contents of my order?
No, the contents of your order with Disulfiram are strictly confidential. All orders are securely packaged without any external labelling that could reveal the contents, ensuring absolute discretion. We prioritise the privacy of our customers, and no third party will be informed of the details of your order.
What is Disulfiram and how does it work?
Disulfiram is a medication used to treat alcohol dependence. It works by causing unpleasant effects when alcohol is consumed, including nausea, vomiting, flushing, and headaches, deterring further drinking.
Is it legal to use Disulfiram in the United Kingdom?
In the United Kingdom, Disulfiram is a prescription medication and can be legally obtained with a valid prescription from a licensed healthcare provider.
Mechanism of action of Disulfiram
Disulfiram inhibits the enzyme aldehyde dehydrogenase, causing an accumulation of acetaldehyde after alcohol consumption, leading to unpleasant effects that discourage further drinking.
How long does it take for Disulfiram to work?
Disulfiram typically begins working within 1-2 hours after taking it, and its effects can last for up to 2 weeks after the last dose.
How long does the effect of Disulfiram last?
The effect of Disulfiram typically lasts for 1 to 2 weeks after the last dose, though it can vary from person to person.
What are the risks of misuse of Disulfiram?
Disulfiram misuse may lead to severe reactions when combined with alcohol, including nausea, vomiting, flushing, and potentially life-threatening complications. Proper medical supervision is crucial to avoid risks.
How long does Disulfiram stay in the body?
Disulfiram is detectable in the body for approximately 1 to 2 weeks after the last dose, with metabolites potentially present for up to 4 weeks.
Will Disulfiram show up in a drug test?
Disulfiram does not typically show up on standard drug tests, but specific tests for this medication may detect its presence.
Compatibility of Disulfiram with other medications
Disulfiram may interact with: – Alcohol – Isoniazid – Metronidazole – Paraldehyde – Certain cough and cold medications Contact our support for more details about drug interactions.
Can one consume alcohol while taking Disulfiram?
No. You must not drink any alcohol while taking disulfiram or for at least a week after stopping it. Even small amounts of alcohol, including alcohol hidden in foods, mouthwashes and some medicines, can cause a severe and potentially dangerous reaction.
Recommended storage method for Disulfiram
Store Disulfiram tablets at room temperature (below 25°C), away from moisture, heat and direct light. Keep the container tightly closed when not in use.
How should Disulfiram be taken and in what dosage?
Disulfiram should be taken once daily with a full glass of water. The usual UK dose is 800 mg on the first day, reduced over five days to 100–200 mg once daily.
| How to take Disulfiram |
|---|
|
Can Disulfiram be taken for an extended period?
Disulfiram can be taken long-term with proper medical supervision, but it’s crucial to follow dosage instructions and consult a healthcare professional regularly for monitoring and adjustments as needed.
Overdose of Disulfiram and what to do in case of an overdose
An overdose of Disulfiram can be harmful, so it is important to seek medical assistance promptly. If you suspect an overdose, you should:
- Contact your doctor or NHS 111 immediately for professional advice, or call 999 in an emergency.
- Closely follow the instructions from your healthcare provider.
- Avoid taking additional doses without consulting a doctor.
Remember, prompt action is crucial.
Comparison of Disulfiram with other analogues
Disulfiram, also known as Antabuse, is a medication primarily used in the treatment of alcohol dependence. It works by inhibiting the enzyme aldehyde dehydrogenase, which is involved in the metabolism of alcohol. This leads to an accumulation of acetaldehyde, causing unpleasant effects like nausea, vomiting, and flushing when alcohol is consumed, deterring further drinking. Other medications used in the treatment of alcohol dependence include naltrexone, which blocks the rewarding effects of alcohol, and acamprosate (Campral), which helps reduce cravings and withdrawal symptoms. Unlike disulfiram, these medications do not cause an adverse reaction when combined with alcohol but work through different mechanisms to support abstinence and prevent relapse.
What you should know before taking Disulfiram
Disulfiram can cause severe reactions with alcohol, including nausea, vomiting, and low blood pressure. It should not be taken if you have severe heart or liver disease or during pregnancy or breastfeeding.
Contraindications for the use of Disulfiram
Disulfiram should be avoided in patients with severe cardiac, respiratory, or neurological diseases, psychosis, hypothyroidism, and those who consume alcohol regularly. Contraindications include hypersensitivity, severe cardiovascular disease, coronary artery disease, hepatic cirrhosis, and concomitant use of certain medications like metronidazole, paraldehyde, or isoniazid.
Possible side effects of Disulfiram
Disulfiram, a medication used in treating alcohol dependence, has some potential side effects. The most common ones include:
- Nausea and vomiting
- Headache
- Drowsiness
- Fatigue
- Skin rash
It’s advisable to consult a healthcare professional for a comprehensive understanding of the risks and benefits associated with Disulfiram.
Lifestyle: diet and physical activity
Disulfiram is not recommended for lifestyle improvements related to diet and physical activity, as it’s a medication primarily used to treat alcohol dependence.
How does mental state affect the effectiveness of Disulfiram
Mental state can impact the effectiveness of Disulfiram, as psychological factors like motivation, stress, and coping mechanisms play a crucial role in addiction treatment. A stable mental state enhances compliance and overall treatment outcomes.
When should one consult a doctor?
When using Disulfiram, it’s crucial to consult a doctor regularly to ensure proper monitoring and management of your treatment. Your doctor can assess potential side effects, adjust dosages if needed, and provide guidance on avoiding alcohol consumption while on this medication. Regular check-ups help maintain the safety and effectiveness of your Disulfiram therapy.
In which cities can Disulfiram be delivered?
Disulfiram is available for delivery in the following cities in the United Kingdom:
| City | Region | Delivery Time |
|---|---|---|
| London | Greater London | 9–21 days |
| Birmingham | West Midlands | 9–21 days |
| Manchester | North West England | 9–21 days |
| Liverpool | North West England | 9–21 days |
| Leeds | Yorkshire and the Humber | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Newcastle upon Tyne | North East England | 9–21 days |
| Sheffield | Yorkshire and the Humber | 9–21 days |
| Bristol | South West England | 9–21 days |
| Edinburgh | Scotland | 9–21 days |
| Belfast | Northern Ireland | 9–21 days |
| Cardiff | Wales | 9–21 days |
For additional locations and delivery enquiries, please contact our support team.
