Levitra with Dapoxetine
Levitra with Dapoxetine
- In our online pharmacy, you can purchase Levitra with Dapoxetine without prescription, with worldwide delivery. Discreet packaging.
- This medication treats both erectile dysfunction (via vardenafil, a phosphodiesterase-5 inhibitor that enhances blood flow) and premature ejaculation (via dapoxetine, a serotonin reuptake inhibitor that delays ejaculation).
- The standard dose is one tablet (20mg vardenafil + 60mg dapoxetine) taken as needed before sexual activity, maximum once daily.
- Administered as a film-coated tablet.
- Effects typically begin within 30–60 minutes after ingestion.
- Duration of action lasts up to 4–5 hours.
- Avoid alcohol consumption as it may worsen side effects like dizziness or low blood pressure.
- Common side effects include headache, flushing, dizziness, nasal congestion, nausea, and insomnia.
- Would you like to try Levitra with Dapoxetine without prescription?
Basic Levitra with Dapoxetine Information
| Parameter | Details | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| INN (International Nonproprietary Name) | Vardenafil (ED) + Dapoxetine (PE) | |||||||||
| Common UK Brand Names |
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| ATC Code | G04BE09 (Vardenafil) + G04BX14 (Dapoxetine) | |||||||||
| Available Forms | Film-coated tablets only | |||||||||
| Standard Strengths |
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| Manufacturers | Primarily Indian companies (e.g., Sunrise Remedies), no EU manufacturers | |||||||||
| UK Regulatory Status | Not MHRA-approved | |||||||||
| Legal Classification | Prescription-only medication (POM) |
Levitra with dapoxetine tablets appear as oval, film-coated pills typically imprinted with strength identification marks such as "VL20" or "VL40" followed by manufacturer codes. The dual-action formulation combines erectile dysfunction treatment with premature ejaculation management in a single tablet. In the UK, you’ll exclusively find versions imported from non-EU countries, mainly India. NHS pharmacies don’t routinely stock this combination due to its unapproved status.
Regulatory Status Across the UK
Neither vardenafil nor dapoxetine have received authorization as a combined product from British or European regulatory bodies. While vardenafil alone is licensed as Levitra and dapoxetine as Priligy, their joint formulation exists in a regulatory grey area. The Medicines and Healthcare products Regulatory Agency categorizes this combination strictly as prescription-only medication. Attempted purchases through online marketplaces without valid NHS prescriptions violate UK medicines regulations.
How Levitra with Dapoxetine Completes Dual Action
The combined tablet works through dual pharmacological pathways targeting different sexual dysfunction mechanisms:
Vardenafil mechanism: As a PDE5 inhibitor, this component enhances nitric oxide effects in penile tissue. By relaxing smooth muscles and dilating blood vessels, it facilitates erectile response adequate for sexual activity. The biochemical process initiates within 30-60 minutes post-ingestion and typically maintains efficacy for 4-5 hours.
Dapoxetine mechanism: This selective serotonin reuptake inhibitor works centrally to increase neurotransmitter activity at synaptic junctions. Elevated serotonin levels delay ejaculatory reflexes, extending intravaginal ejaculation latency time without sedating effects.
Both compounds undergo hepatic metabolism primarily through the CYP3A4 enzyme pathway, creating potential for interaction with various medications and foods. Fatty meals may slow absorption, while alcohol can exacerbate side effects like dizziness or orthostatic hypotension without necessarily enhancing therapeutic outcomes.
NHS-Indicated Uses and Limitations
⚠️ Paediatric restriction: Strictly contraindicated for individuals under 18 years.
The medication targets simultaneous erectile dysfunction and premature ejaculation in adults where both conditions co-exist. Off-label use occasionally occurs for performance anxiety-related premature ejaculation when SSRIs prove unsuitable. The NHS doesn't recommend routine prescribing of unapproved combination products when monotherapy alternatives exist. Pregnancy constitutes another major contraindication (category B classification) due to limited safety data.
Medically appropriate usage involves strict prescriber supervision due to cardiovascular contraindications. These include severe systemic hypertension, unstable angina, recent cardiovascular incidents, and concomitant nitrate therapy that could trigger dangerous hypotension.
Basic Product Identification & Forms
Levitra with Dapoxetine combines two distinct medications under one formulation. The international nonproprietary names (INNs) are Vardenafil for erectile dysfunction treatment and Dapoxetine for premature ejaculation management. In the UK market, you'll commonly find this combination sold under brand names like Super Vilitra or Levitra with Dapoxetine, typically manufactured by Indian pharmaceutical companies such as Sunrise Remedies. EU-origin versions remain unavailable through NHS channels.
The medication exclusively comes as film-coated tablets with two strength variations:
| Vardenafil Strength | Dapoxetine Strength | Packaging Options |
|---|---|---|
| 20mg | 60mg | 4, 10, or 20 tablets |
| 40mg | 60mg | 4, 10, or 20 tablets |
Physically, these tablets feature distinctive imprints indicating their dual-component nature. Typical identifiers include "VL" or "SP" codes alongside dosage markings like "20/60". Creams, injections, or other formulations don't exist for this particular combination.
Regulatory Status & Legal Classification
This combined medication lacks approval from major regulatory bodies. Neither the European Medicines Agency (EMA) nor the US Food and Drug Administration (FDA) have authorised Levitra with Dapoxetine. Within UK jurisdiction, the Medicines and Healthcare products Regulatory Agency (MHRA) classifies it as prescription-only medicine (POM), meaning it cannot be legally obtained without a valid prescription.
For context, both individual components have separate regulatory statuses: Vardenafil (as Levitra) holds EMA approval for erectile dysfunction, while Dapoxetine (as Priligy) is licensed for premature ejaculation treatment. Their combined formulation falls outside approved indications.
Dual-Action Pharmacology
The medication works through two distinct physiological pathways addressing different aspects of sexual dysfunction. Vardenafil inhibits phosphodiesterase type 5 (PDE5) enzymes, causing smooth muscle relaxation in penile tissues. This increases blood flow necessary for erections when sexual stimulation occurs.
Meanwhile, dapoxetine modulates serotonin neurotransmission as a selective serotonin reuptake inhibitor (SSRI). By extending serotonin activity within the central nervous system, ejaculatory reflexes are delayed without numbing sensation.
The pharmacological profile reveals critical considerations:
- Onset occurs 30-60 minutes post-ingestion
- Effects last approximately 4-5 hours
- Peak plasma concentration: Vardenafil (0.5-1 hr), Dapoxetine (1-2 hrs)
- Primary metabolism occurs via hepatic CYP3A4 enzymes
- High-fat meals delay absorption
Alcohol consumption significantly increases risks of hypotension and adverse reactions. Furthermore, interactions with nitrates or alpha-blockers can cause dangerous blood pressure drops.
Clinical Applications
Levitra with Dapoxetine serves as a dual-purpose treatment for men experiencing concurrent erectile dysfunction and premature ejaculation. NHS guidelines classify this combined application as off-label, meaning it falls outside officially approved indications. Some urologists prescribe it when monotherapies prove inadequate for comorbid conditions.
Absolute contraindications extend to several patient groups:
- Cardiovascular disease patients using nitrates
- Severe hepatic impairment cases
- Concurrent users of MAO inhibitors or recreational drugs
The medication carries Category B pregnancy risk classification. While animal studies show no fetal harm, adequate human pregnancy studies remain unavailable. Breastfeeding mothers should also avoid use due to excretion risks in human milk.
Clinical Applications of Levitra with Dapoxetine
The combination of levitra (vardenafil) and dapoxetine targets erectile dysfunction (ED) alongside premature ejaculation (PE). Vardenafil enhances blood flow for erections, while dapoxetine – an SSRI – delays ejaculation by affecting brain chemicals. Crucially, this fixed-dose combo isn’t approved by the European Medicines Agency (EMA). I work closely with NHS guidelines daily, and must stress this medication falls under *off-label status* here – meaning it’s prescribed exceptionally when alternatives fail.
- Under-18s: Strictly contraindicated. Never prescribed to adolescents.
- Severe liver impairment: Eliminates drugs slower, raising toxicity risks.
- Pregnancy: While primarily for males, accidental exposure risks exist. Vardenafil is Category B (animal studies show no harm but human data limited).
Despite no formal approval, some specialists consider this duo for anxiety-related PE where psychological factors worsen both conditions. Even then, I’ve observed stringent NHS protocols: thorough cardiac assessment precedes any off-label script. It’s never first-line and requires consultant oversight.
