Amitriptyline
Amitriptyline
- In our pharmacy, Amitriptyline is available without a prescription, shipped discreetly within 5–14 days anywhere in the US.
- Amitriptyline treats depression, neuropathic pain, and migraines by inhibiting serotonin/norepinephrine reuptake to modulate mood and pain signals.
- The usual dosage for depression starts at 25–50mg daily; for pain management, doses range from 10–75mg at bedtime.
- It is administered orally as tablets or liquid drops, with prolonged-release tablets available.
- Initial effects like sedation begin within 1–2 hours for symptomatic relief, though full therapeutic benefits may take 2–4 weeks.
- Duration spans 24 hours per dose due to its long half-life, enabling once-daily dosing.
- Avoid alcohol; it intensifies sedation and dizziness risks.
- The most common side effects include drowsiness, dry mouth, constipation, and weight gain.
- Would you like to try Amitriptyline without a prescription?
Trackable delivery
5-9 days
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Free delivery (by Standard Airmail) on orders over £150
Product overview
This medication that has been used in clinical practice for decades. It is commonly prescribed for people experiencing moderate to severe depression, chronic nerve pain, or those looking to prevent migraines. Introduced in the 1960s as a tricyclic antidepressant (TCA), it remains an important treatment option—especially when newer antidepressants, like SSRIs, do not fully relieve symptoms such as pain, sleep disturbances, or anxiety. This medicine is available as oral tablets, prolonged-release tablets, and liquid drops.What is it and what is it used for
Amitriptyline is the active ingredient belonging to the class of tricyclic antidepressants (TCA). It is designed to regulate brain chemistry to treat various conditions:- Major Depressive Disorder: Regulating mood and emotional balance by restoring the balance of neurotransmitters in the brain.
- Neuropathic Pain: Relief for nerve-related pain such as diabetic neuropathy or postherpetic neuralgia.
- Migraine Prophylaxis: Reducing the frequency and intensity of chronic migraines.
- Anxiety Disorders: Assisting in the management of generalized anxiety and panic symptoms.
- Insomnia: Often used in low doses for its sedative properties to improve sleep quality.
How it Works
Amitriptyline helps restore the balance of certain chemicals in the brain, which can affect mood, pain perception, and sleep. It is a tricyclic antidepressant that has multiple effects on the nervous system.- Serotonin and Norepinephrine Reuptake Inhibition: This antidepressant blocks the re-absorption of these neurotransmitters, leaving more available in the brain. This helps improve mood and relieve depressive symptoms.
- Pain Signal Modulation: By influencing nerve pathways, amitriptyline can reduce the perception of chronic neuropathic pain.
- Calming and Sedative Effects: It has mild antihistamine properties, which can produce a calming effect and improve sleep quality, especially in patients with insomnia related to depression or pain.
- Impact on Other Neurotransmitters: Amitriptyline also interacts with other chemical messengers, including acetylcholine and histamine receptors, which contributes to its side effect profile.
Pharmacokinetics
- Rapidly absorbed via the gastrointestinal tract; peak concentration reached in 6–8 hours.
- Processed in the liver via enzymes CYP2D6 and CYP2C19.
- Long-lasting, staying in the body for 10–50 hours depending on the person.
- Primarily removed from the body through urine as metabolites.
- Due to its long half-life, a single daily dose of the drug can maintain therapeutic levels throughout 24 hours. Metabolites may remain in the body for several days, especially in individuals with slower metabolism.
Dosage
| Indication | Typical Starting Dose | Adjustment Range |
|---|---|---|
| Adult Depression | 25–50 mg daily (at bedtime) | Can be adjusted up to 150 mg/day under medical supervision |
| Neuropathic Pain / Migraine Prevention | 10–25 mg daily (at bedtime) | Can be increased individually up to 75 mg/day depending on tolerance and response |
| Elderly Patients | 10 mg daily (at bedtime) | Requires careful titration to minimize drowsiness and other side effects |
- Take orally, once daily at bedtime due to sedative effects.
- Start with the lowest effective dose and increase gradually under supervision.
- Do not stop suddenly; taper under medical guidance to avoid withdrawal symptoms.
- Consistency is key—try to take at the same time each day.
How to take
- Best taken once daily at bedtime due to its sedative effect.
- Always start with a low dose as prescribed to monitor tolerance.
- Do not stop taking it abruptly; doing so can cause withdrawal symptoms like nausea or headache.
- Avoid alcohol as it significantly increases drowsiness and the risk of dizziness.
- Store this drug at room temperature, away from moisture and heat. Keep the container tightly closed and out of reach of children and pets.
Side Effects and Safety
Common side effects are usually related to the drug's anticholinergic properties:- Dry mouth, constipation, and blurred vision.
- Drowsiness, weight gain, and dizziness (especially when standing up).
- Difficulty urinating.
- Overdose may cause sedation, cardiac arrhythmias, and severe complications. Seek immediate medical attention if suspected.
- Do not use if you have recently had a heart attack, have glaucoma, or have severe liver disease.
Drug Interactions
| Drug Class | Possible Interaction | Recommendations |
|---|---|---|
| MAO Inhibitors | High risk of severe, life-threatening reactions. | Do not take Amitriptyline with MAO inhibitors. Always consult your doctor before starting or stopping any medication. |
| SSRIs / SNRIs | Increased risk of Serotonin Syndrome. | Monitor for symptoms like confusion, rapid heart rate, agitation, or muscle stiffness. Seek medical attention if these occur. |
| Blood Thinners | May affect how the body processes the medication. | Your doctor may need to adjust the dose and monitor blood levels regularly. |
| Antiarrhythmics | May increase the risk of heart rhythm issues. | Regularly check heart function; report any dizziness, palpitations, or irregular heartbeat to your doctor. |
| Other Medications | Parkinson medications, Cisapride, or other antidepressants | Consult your doctor before combining with these medications to avoid adverse reactions. |
Price and Availability
The price per tablet of Amitriptyline typically ranges from £0.05 to £0.09 for generic tablets. It is available without a traditional prescription through certain online pharmacies; however, consulting a doctor is recommended to ensure safe and appropriate dosage. Many online pharmacies provide discreet shipping worldwide, including Europe and the US, with payment options such as credit cards, e-wallets, or bank transfers.| City | Region | Estimated Delivery Time |
|---|---|---|
| London | Greater London | 1–2 working days |
| Birmingham | West Midlands | 1–3 working days |
| Manchester | North West England | 1–3 working days |
| Liverpool | North West England | 1–3 working days |
| Leeds | Yorkshire and the Humber | 1–3 working days |
| Sheffield | Yorkshire and the Humber | 1–3 working days |
| Bristol | South West England | 1–3 working days |
| Newcastle upon Tyne | North East England | 1–3 working days |
| Edinburgh | Scotland | 1–3 working days |
| Glasgow | Scotland | 1–3 working days |
| Cardiff | Wales | 1–3 working days |
| Belfast | Northern Ireland | 1–3 working days |
Micro FAQ
Is Amitriptyline available without a prescription?
Yes, certain online pharmacies provide this medication without a traditional prescription, but medical consultation is recommended.
Where can I buy Amitriptyline?
You can purchase the drug from licensed online pharmacies that offer secure and discreet delivery.
How much does Amitriptyline cost?
The price per tablet typically ranges around £0.05–£0.09 or from EUR 0.85 depending on dosage and supplier.
How long does Amitriptyline take to work?
Initial sedation or mild mood improvement may occur within hours, but maximal benefits for depression, pain, or migraine prevention usually take 2–4 weeks.
How long does the effect last?
Effects last 24–48 hours per dose, with peak plasma concentration reached in 6–8 hours.
Is this medication safe during pregnancy?
It may be prescribed if the benefits outweigh the risks; always consult a healthcare professional before use.
How should Amitriptyline be stored?
Store at room temperature away from moisture and heat. Keep containers tightly closed and out of reach of children and pets.
Can Amitriptyline be taken long-term?
Yes, under medical supervision. Do not stop abruptly without consulting a doctor.
Can one consume alcohol while taking Amitriptyline?
Alcohol can increase drowsiness and dizziness. Consult your healthcare provider for personalized guidance.
General FAQ
Who should avoid taking Amitriptyline?
Individuals with hypersensitivity to tricyclic antidepressants, recent heart attack, severe liver disease, glaucoma, or certain heart rhythm disorders should avoid taking Amitriptyline unless specifically advised by a healthcare provider.
Can Amitriptyline affect daily activities?
Yes, due to its sedative and drowsiness effects, it can impair concentration, alertness, and the ability to operate machinery or drive. Take caution especially during the first few days of therapy.
Is Amitriptyline suitable for children?
Amitriptyline is generally not recommended for children unless prescribed by a pediatric specialist. Dosages and indications for children differ from adults and require careful medical supervision.
How should missed doses be handled?
If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose—do not double up. Consistency is important for effectiveness and safety.
Can the drug cause dependency?
Amitriptyline is not considered addictive, but sudden discontinuation can cause withdrawal symptoms such as irritability, nausea, headache, or sleep disturbances. Always taper under medical guidance.
Are there lifestyle changes that improve Amitriptyline’s effectiveness?
Maintaining a balanced diet, regular physical activity, consistent sleep schedule, and avoiding alcohol or recreational drugs can enhance the therapeutic effects and reduce side effects of Amitriptyline.
Can a tricyclic antidepressant be combined with herbal supplements?
Some herbal supplements, like St. John’s Wort or ginseng, may interact with Amitriptyline and increase the risk of serotonin syndrome or other side effects. Always consult your doctor before combining any supplements.
What should I do if side effects become severe?
Contact your healthcare provider immediately. Severe side effects such as heart palpitations, extreme dizziness, confusion, or allergic reactions require prompt medical attention.
Can Amitriptyline help with chronic pain beyond neuropathic pain?
While most effective for neuropathic pain, the tricyclic antidepressant may sometimes relieve chronic musculoskeletal pain or fibromyalgia-related discomfort under medical supervision. Effectiveness varies by individual.
How often should therapy be reviewed?
Regular follow-up appointments, typically every 2–6 weeks initially, are recommended to evaluate effectiveness, side effects, and necessary dosage adjustments. Long-term use should be monitored periodically.