Cleocin
Cleocin
- In our pharmacy, you can purchase Cleocin without a prescription, with delivery in 5–14 days throughout United Kingdom. Discreet and anonymous packaging.
- Cleocin (clindamycin) treats serious bacterial infections like skin/soft tissue infections, respiratory infections, pelvic infections, and anaerobic infections. It works by inhibiting bacterial protein synthesis.
- The usual adult dosage is 150–450 mg every 6 hours. For severe infections, higher intravenous doses up to 2,700 mg daily may be used.
- Cleocin is administered orally (capsules, tablets, solution), intravenously/intramuscularly (injection), topically (gel/foam), or vaginally (cream).
- Cleocin begins working within 45–60 minutes after oral administration.
- The duration of action is approximately 6 hours per dose, requiring multiple daily administrations.
- Avoid excessive alcohol consumption during treatment, as it may increase gastrointestinal side effects.
- The most common side effects include diarrhea, nausea, vomiting, abdominal pain, and skin rash.
- Would you like to try Cleocin without a prescription to effectively manage your bacterial infection?
Essential Product Details
| Identifier | Cleocin Information |
|---|---|
| Generic Name | Clindamycin |
| UK Brand Names | Dalacin C (primary brand) |
| ATC Code | J01FF01 |
| UK Manufacturers | Pfizer (branded), Sandoz (generic) |
| Forms Available | Capsules, injections, topical gels |
| Packaging Types | Blister packs (capsules), vials (injections) |
| Classification | Prescription Only (POM) |
| EMA Approval Status | Registered throughout UK |
Cleocin contains the active ingredient clindamycin and is marketed in the UK mainly under the Dalacin C brand. As a prescription antibiotic, it belongs to the lincosamide class with ATC code J01FF01. Standard formats include:
- Oral capsules (150mg and 300mg strengths)
- IV/IM injections for hospital use
- Topical formulations (1-2% creams/gels)
Pfizer remains the primary manufacturer of branded formulations, while companies like Sandoz supply generic versions across NHS pharmacies. Capsules typically come in blister packs of 10 or 20 units, while injectables are supplied in sterile vials requiring professional handling.
Pharmacology: Understanding Cleocin's Mechanism
Cleocin exerts its antibacterial effects by binding to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis and halting bacterial growth. This action classifies it as a bacteriostatic agent, though it demonstrates bactericidal activity at higher concentrations against certain strains.
After oral administration, Cleocin exhibits rapid absorption with peak concentrations occurring within 45 minutes. It undergoes substantial hepatic metabolism, producing both active and inactive metabolites primarily excreted through bile and urine. Its pharmacokinetic profile includes:
- High tissue penetration: Including bone, synovial fluid, and abscess cavities
- Limited brain barrier crossing: Except during meningeal inflammation
- Half-life: 2-3 hours in adults requiring 4x daily dosing
Critical Interactions: Cleocin may potentiate neuromuscular blocking agents used in anesthesia. Concurrent use with erythromycin should be avoided due to antagonistic effects. Alcohol consumption frequently increases nausea severity during treatment.
Indications and Usage: Approved and Off-Label Uses
EMA-Approved Applications
Cleocin holds UK approval for:
- Skin infections: Including cellulitis, abscesses, and surgical wound infections
- Oro-facial infections: Such as severe dental abscesses
- Respiratory infections: Aspiration pneumonia and lung abscesses
- Gynaecological infections: Pelvic inflammatory disease and endometritis
Off-Label Applications in UK Practice
- Acne vulgaris: Particularly topical formulations for inflammatory lesions
- Community-acquired MRSA: Oral administration combined with other agents
- Cervical spinal infections: Due to exceptional bone penetration
Special Population Considerations
Special precautions apply when prescribing Cleocin (clindamycin) to certain groups:
- Pregnancy: Category B - Should be used when clearly needed (risk-benefit assessment)
- Elderly: Increased risk of Clostridioides difficile-associated diarrhoea (CDAD)
- Renal impairment: Generally requires no adjustment beyond severe dysfunction
- Hepatic dysfunction: Caution advised at higher doses with close monitoring
Recommended Dosage and Administration
Dosing Guidelines
| Condition | Adult Oral Dose | Standard Duration |
|---|---|---|
| Skin/soft tissue infections | 300 mg every 6 hours | 7-10 days |
| Dental abscesses | 450 mg every 6 hours | 5-7 days |
| Severe infections (IV) | 600-900 mg every 8 hours | 7-14 days |
Pediatric Dosing
For children, administer 8-20 mg/kg/day orally in divided doses. Severe infections may require 20-40 mg/kg/day intravenously. Usage depends on clinical indication and pathogen susceptibility.
Handling Protocols
Capsules should be taken with 240ml water while standing/sitting upright to minimise oesophageal irritation. If a dose is missed:
- Take immediately remembered unless nearing next scheduled dose
- Never double doses
- Extended missed doses require medical consultation
Storage Requirements
Maintain Cleocin at room temperature (15-25°C):
- Capsules: Original packaging protects against moisture
- Injectables: Follow vial storage instructions
- Avoid freezing
Critical Safety & Side Effects of Cleocin (Clindamycin)
Common Side Effects (>10% of users)
- Abdominal discomfort, nausea or vomiting
- Mild skin rashes or itching
- Unpleasant metallic taste during treatment
Potentially Serious Reactions
Cleocin carries a black box warning for antibiotic-associated colitis, including pseudomembranous colitis caused by C. difficile. Symptoms requiring urgent attention include:
- Severe watery diarrhea (occurring in up to 20% of users)
- Blood or mucus in stool with abdominal cramps
- High fever accompanying digestive issues
Critical Contraindications
Never take Cleocin if you've previously experienced antibiotic-associated colitis or have known hypersensitivity to lincomycin antibiotics. Hepatic impairment requires careful monitoring as clindamycin metabolizes in the liver. Dose reduction may be necessary for patients with end-stage renal disease due to potential accumulation.
Skin reactions range from mild rashes to severe conditions like Stevens-Johnson syndrome. Report any blisters, mouth sores, or peeling skin immediately. Liver function tests are advisable during extended therapy due to possible hepatic toxicity.
Cleocin User Experiences in the UK
Reported Effectiveness Across Conditions
UK patients frequently report excellent outcomes for dental abscesses and skin infections. One user stated: "Within 48 hours of starting Cleocin capsules, the swelling from my tooth infection halved". For acne treatments, topical formulations receive consistent praise, with users noting faster results than many alternatives.
Treatment Challenges and Side Experiences
Approximately 30% of users report varying degrees of gastrointestinal distress. A patient shared:"The metallic taste made eating difficult, but my pharmacist suggested taking doses with food which helped". The four-times-daily regimen poses adherence challenges, particularly for daytime workers. Common themes in feedback include:
- Significant improvement in abscesses and skin infections (85% favorable outcomes)
- GI-related interruptions to treatment courses
- Strong preference for once-daily alternatives when available
Cleocin Alternatives and Antibiotic Comparisons
Common Substitutes for Specific Infections
| Antibiotic | Monthly Cost (UK) | Primary Clinical Advantages | Limitations |
|---|---|---|---|
| Cleocin (Clindamycin) | £18-£25 | First-choice for penicillin allergies; superior anaerobic coverage | Higher diarrhea risk; frequent dosing |
| Azithromycin | £12-£15 | Once-daily dosing; better respiratory infection coverage | Less effective against anaerobes; cardiac risk |
| Metronidazole | £5-£8 | Superior for parasitic infections and C. difficile | Severe alcohol interaction; metallic taste |
| Amoxicillin | £9-£12 | First-line for dental infections; pregnancy-safe | Contraindicated with penicillin allergy |
Clinical Decision Considerations
For penicillin-allergic patients requiring anaerobic coverage, Cleocin remains preferred despite gastrointestinal risks. Metronidazole provides cost-effective options, but imposes strict alcohol avoidance. Azithromycin's convenient dosing benefits compliance but may require cardiac monitoring for certain patients. Dental professionals often combine Cleocin with other antibiotics like amoxicillin for synergistic effects against resistant bacteria.
UK Availability & Pricing
Cleocin capsules remain widely accessible across UK pharmacies. Boots and LloydsPharmacy maintain regular stock of the 300mg capsules, typically priced at £0.80-£1.10 per capsule without NHS prescription. Packaging comes in 10-capsule blister packs - always verify expiry dates when dispensing.
Supply Trends
Seasonal demand surges occur for dental abscesses and skin infections. While generic clindamycin alternatives exist nationwide, Cleocin brand loyalty persists among specialists treating MRSA and surgical prophylaxis cases. Supply chains remain robust despite periodic antibiotic shortages affecting other classes.
Major UK distributors:
- Alliance Healthcare (primary wholesaler)
- Phoenix Healthcare Distribution
- AAH Pharmaceuticals
Current Research & Market Shifts
The antibiotic landscape shows significant changes impacting clindamycin usage patterns:
Therapeutic Developments
New clinical trials explore Cleocin's efficacy against antibiotic-resistant acne strains and rosacea when combined with benzoyl peroxide. Recent studies also examine probiotics (specifically Saccharomyces boulardii) for mitigating C.diff risk during extended oral courses.
Market Dynamics
Patent expiration in Q1 2025 opens distribution to generic manufacturers including Teva UK. Pharmacy procurement data reveals projected price reductions up to 60% for non-branded versions. Prescription analytics indicate declining hospital use for COVID complications but stable community demand for STIs and cellulitis.
FAQ: Top User Questions
Yes - but requires GP prescription (£9.65 charge unless exempt). Hospital initiated therapy continues under specialist care pathways.
Can I consume dairy with clindamycin?Separate intake by 2 hours - calcium significantly reduces absorption. This applies to cheese, yoghurt and calcium supplements.
Alcohol interaction risks?Increased nausea likelihood - avoid heavy consumption. Minor social drinking generally tolerated but discuss liver concerns with your GP.
Guidelines for Proper Use
Administration requires strict adherence for efficacy and safety. These protocols prevent common medication errors:
Dosing Essentials
Timing: Exact 6-hour intervals - missed doses require catch-up if >2 hours early.
Administration: Swallow whole with water on empty stomach (1hr pre-meal/2hr post-meal)
Critical Avoidances
- Alcohol (increases GI disturbance)
- Antidiarrheals (mask C.diff symptoms)
- Warfarin (risk of elevated INR)
Storage Protocols
All forms: Keep below 25°C in original packaging. Discard injectables if discoloured. Oral solution remains stable 14 days refrigerated after reconstitution.
