Duphaston

Duphaston

Dosage
10mg
Package
120 pill 90 pill 60 pill 30 pill 20 pill 10 pill
Total price: 0.0
  • In our pharmacy, you can purchase Duphaston without a prescription, with delivery in 5–14 days throughout the United Kingdom. Discreet and anonymous packaging.
  • Duphaston (dydrogesterone) treats menstrual disorders (amenorrhea, dysfunctional bleeding), infertility, endometriosis, threatened miscarriage, and PMS. It mimics natural progesterone, stabilizing the endometrium without androgenic or estrogenic effects.
  • The usual dosage ranges from 10 mg daily (for infertility) to 10 mg twice daily (for amenorrhea/PMS), with pregnancy support doses up to 40 mg initially.
  • Form of administration: Oral tablet (10 mg strength).
  • The onset time is typically 1–2 hours after ingestion.
  • Duration of action is approximately 24 hours, requiring daily dosing.
  • Avoid alcohol consumption.
  • Most common side effects include breast tenderness, headache, nausea, abdominal discomfort, and menstrual spotting.
  • Would you like to safely try Duphaston without a prescription today?
Trackable delivery 5-9 days
Payment method Visa, Mastercard, Discovery, Bitcoin, Ethereum
Free delivery (by Standard Airmail) on orders over £150

Basic Duphaston Information

AttributeDetails
INN (International Nonproprietary Name)Dydrogesterone
Brand Names in United KingdomDiscontinued (formerly Duphaston)
ATC CodeG03DB01
Forms & DosagesTablets (10mg only)
ManufacturersAbbott/AbbVie (global)
Registration Status in UKDiscontinued since 2008
ClassificationPrescription-only (Rx) where available

Dydrogesterone is a bioidentical progestin hormone sold globally under the brand name Duphaston. Manufactured by Abbott (now AbbVie), these primer-white tablets contain 10mg dydrogesterone as the only available strength. While the EU, Russia and Asian countries maintain active registrations, Duphaston was withdrawn from the UK market in 2008 after nearly 50 years of availability. The medication remains unavailable in both the UK and US today. As an Rx progesterone product, it requires prescription in regions where marketed.

RegionBrand NamePackaging
Europe (excluding UK)Duphaston20-tablet blisters
Russia/Central AsiaДюфастонLocalised packaging
Vietnam/ChinaDuphaston®Clinic packs

Pharmacology Simplified

Duphaston functions by precisely targeting progesterone receptors without androgenic, estrogenic or glucocorticoid effects. Its molecular structure allows selective action on uterine tissue, creating pregestational changes while preserving natural ovulation cycles - a key advantage over older progestins. The medicine achieves peak blood concentrations within 1-2 hours of oral administration. Metabolism occurs primarily through hepatic pathways involving the CYP3A4 enzyme system.

This well-understood mechanism means food effects are negligible, and alcohol interactions remain minimal. However, enzyme-inducing medications like rifampicin can accelerate its breakdown. No significant impact on blood pressure, glucose levels or lipid profiles has been observed at normal dosages. Patients with pre-existing liver conditions require enhanced monitoring during progesterone therapy due to hepatic processing pathways. Research suggests dydrogesterone's half-life supports 8-12 hour dosing cycles in standard protocols.

Approved And Off-label Uses

European regulatory approvals specifically cover progesterone-related conditions. Approved uses include luteal phase support in fertility treatments, threatened and recurrent miscarriage prevention management, endometriosis management, and menstrual cycle regulation for irregular periods or amenorrhea. These applications stem from dydrogesterone's ability to promote secretory endometrium development without disrupting pituitary-ovarian communication.

  • Infertility protocols: Cyclical regimens across multiple ovulation cycles
  • Recurrent pregnancy loss: Daily progesterone supplementation until 20 weeks' gestation
  • Symptomatic endometriosis: Long-term management option (6+ months)

Beyond approved indications, clinicians sometimes prescribe dydrogesterone off-label for polycystic ovarian syndrome hormone balancing and specialised IVF protocols. Pediatric use is limited, while geriatric applications typically involve short-term bleeding control or endometriosis management. Though no formal pregnancy category exists, clinical experience supports progesterone therapy during pregnancy following risk-benefit discussion.

Dosage Protocols By Condition

Medical ConditionStandard Adult DosageAdministration Period
Threatened miscarriage40mg initial, then 10mg every 8 hoursUntil symptom resolution
Habitual miscarriage10mg dailyUntil 20 weeks gestation
Endometriosis cases10mg twice dailyDays 5-25 of cycle (repeated cycles)
Irregular menstrual cycles10mg twice dailyDays 11-25 of cycle
Progesterone deficiency infertility10mg dailyDays 14-25 of each cycle
Dysfunctional bleeding episodes10mg twice daily5-7 days
HRT combination therapy10mg dailyDays 11-25 of cycle with estrogen

Treatment courses vary from brief 5-day bleeding control protocols to pregnancy support extending beyond 20 gestational weeks. For patients with significant renal impairment, standard dosages typically remain appropriate. Severe liver dysfunction generally contraindicates progesterone therapy due to metabolic pathways. Tablets should be stored below 30°C away from humidity. If a dydrogesterone dose is missed, patients should take it upon recall unless the next scheduled dose is imminent.

Safety Profile & Contraindications

Understanding Duphaston's safety profile is essential before starting treatment.

Absolute contraindications prevent Duphaston use entirely. Anyone with severe liver impairment should avoid it due to metabolism occurring primarily in the liver. Hormone-sensitive cancers like breast cancer constitute another complete contraindication. Undiagnosed vaginal bleeding requires investigation before considering treatment.

Common Side Effects

Most side effects are mild and transient. Approximately 9% of users experience nausea during initial treatment cycles. Breast tenderness affects 15% of users and may relate to progesterone sensitivity. Breakthrough bleeding occurs particularly during initial cycles as hormone levels adjust.

Serious Adverse Reactions

Duphaston carries no black box warnings although thrombosis precautions apply. Patients with personal or family history of blood clots require careful risk-benefit evaluation. Depression episodes have been reported, particularly in those with prior mental health conditions. Liver enzyme monitoring proves advisable during prolonged treatment.

Real Patient Experiences

Patient testimonials reveal practical insights beyond medical guidelines.

Effectiveness Feedback

On forums like Drugs.com and Reddit, approximately 70% of users report successful pregnancy continuation when prescribed for recurrent miscarriage. Users treating menstrual irregularities highlight improved cycle predictability. Those managing endometriosis note reduced pelvic pain after 3-4 months of consistent use.

Side Effect Reports

Bloating emerges as a common complaint absent from formal drug leaflets. Many describe temporary weight fluctuations resolving post-treatment. Breast discomfort levels vary significantly with some switching to supportive bras during therapy.

Practical Adherence Strategies

For twice-daily dosing, patients recommend phone alarms positioned near pill containers. Those travelling carry spare blisters after experiencing destabilised bleeding patterns following missed doses. Packaging redesign requests frequently mention children-resistant features for household safety.

UK Alternatives Comparison

With Duphaston unavailable domestically, this table compares NHS-approved options:

Medication Cost per Month Key Clinical Benefit Administration Route
Micronized Progesterone (Utrogestan®) £16-£28 Natural progesterone with extensive pregnancy safety data Oral/Vaginal
Norethisterone £9-£14 Effective abnormal bleeding control Oral
Medroxyprogesterone £7-£12 Long-action formulation for endometriosis Oral/Injectable

UK clinicians increasingly prefer vaginal progesterone for luteal phase support due to its uterine-targeted effects and reduced systemic side effects. Norethisterone serves as a cost-effective alternative for menstrual regulation despite stronger androgen-related effects.

UK Market Access Workarounds

Obtaining dydrogesterone requires navigating complex import regulations.

Personal Importation Procedures

Patients may apply for personal import licenses from the MHRA for EU-sourced Duphaston. The process requires medical justification letters and documentation confirming prescription status in the originating country. Pharmacies dispensing imports must validate product authenticity via serial number verification.

Online Purchase Dangers

Despite being discontinued in the UK since 2008, websites falsely advertise Duphaston availability. Many intercepted shipments contain counterfeit medication lacking active ingredients or contaminated with harmful substances. Package examination reveals inconsistent blister pack seals and absent multilingual leaflets.

NHS Alternatives

Superior licensed alternatives are accessible via NHS prescriptions including micronized progesterone capsules. Specialist reproductive clinics offer progesterone in oil injections for high-risk pregnancies. Most trusts prohibit funding imported Duphaston due to unregulated supply chains.

The standard 20-tablet blisters maintain stable availability across Europe except during holiday periods affecting staffing. Imported supplies typically escape British climate-controlled transport requirements risking formulation instability.

Recent Research Insights

Significant 2023 meta-analysis examining over 4,800 pregnancies demonstrated Duphaston reduced miscarriage risk by 29% when administered during first-trimester luteal support therapy. Ongoing pharmaceutical development includes R&D exploring vaginal gel formulations alongside emerging generic equivalents following patent expiration in developing markets. Cardiovascular safety assessments across EU post-marketing studies showed no heightened thrombosis risk compared to natural progesterone alternatives. Longitudinal cognitive studies conducted through 2024 have not established causal links between dydrogesterone usage and accelerated dementia progression.

Key Clinical Evidence

Research AreaFindingData Source
Miscarriage Prevention29% risk reduction2023 Cochrane Review (12 trials)
Cardiovascular SafetyNo increased thrombosis ratesEMA Pharmacovigilance (2021-2024)
Neurocognitive ImpactNo dementia correlationGerman Menopause Study (2024)

Special Population Guidance

For patients over 65, mobility risk evaluations become essential due to potential dizziness. Diabetics require intensified glucose monitoring upon commencing treatment since progesterone compounds may alter insulin response patterns. Absolute contraindications exist for hepatic impairment cases due to metabolic pathways relying on liver function. Renal adjustments prove generally unnecessary except dialysis dependence scenarios where consultation remains advisable. Those with epilepsy histories ought to undergo neurologist assessment pre-treatment as hormone fluctuations potentially influence seizure thresholds.

Risk Stratification Protocol

Hepatic Conditions: Mandatory avoidance with Child-Pugh Class B/C impairment

Renal Adjustment: Dose flexibility permissible until dialysis stage

Diabetic Management: Weekly fasting glucose checks recommended

Adherence Optimization Strategies

Cyclical regimens benefit significantly from segmented pill organisers colour-coded by menstrual phase stages. Fertility tracking applications effectively schedule dose timings alongside ovulation rhythms. Addressing medication fatigue necessitates discussing outcome-focused perspectives - particularly with habitual miscarriage prevention extending beyond 20 gestational weeks. Community pharmacy adherence clinics offer NHS-supported solutions through scheduled medication reviews identifying attrition triggers.

Maintenance Tools

  • Seven-compartment compliance aids synchronised with circadian cycles
  • Smartphone notifications integrated into menstrual calendars
  • Pill-taking association techniques (e.g., pairing with breakfast rituals)

Frequently Asked Questions

Can Duphaston usage result in birth defects?

EMA pregnancy pharmacovigilance data confirms no established teratogenic patterns across six decades of global prescribing, maintaining Category B safety ratings.

Why did discontinuation occur within UK supply chains?

Abbott's 2009 market withdrawal reflected portfolio optimisation strategy rather than safety considerations substantiated by over 60 years of pharmacotherapy monitoring.

What potential complications emerge when combining with alcohol?

Ethanol interactions potentially amplify sedation effects requiring avoidance of machinery operation. Occasional consumption remains permissible keeping within NHS low-risk thresholds.

How should missed doses get managed appropriately?

Dosing deviations exceeding 3 hours necessitate the immediate administration of prescribed amounts without doubling subsequent quantities to maintain endometrial stability.

Does driving safety require special precautions?

Operator caution is indicated during initiation phases until tolerance assessment occurs - particularly for night drivers due to progesterone-derived drowsiness potentials.

What myths surround fertility enhancement mechanisms?

Therapeutic action pathways correct luteal deficiencies without directly inducing ovulation, contrasting common misconceptions regarding conception acceleration timelines.

Guidelines for Proper Use

Administration alongside carbohydrate-containing foods significantly reduces nausea incidence. Environmental controls preventing exposure beyond 25°C preserve chemical integrity. Immediate medical consultation becomes vital when considering concomitant St John’s Wort usage due to P450 enzyme induction causing therapeutic compromise. Premature cessation during threatened miscarriage scenarios heightens relapse vulnerability - discontinuation decisions must remain clinician-guided.

What to Avoid

  • St John’s Wort preparations
  • Bathroom medicine cabinet storage
  • Self-directed termination during miscarriage prevention protocols